Which of the following signs is consistent with somatostatinoma?

Somatostatinoma is a rare neuroendocrine tumor that typically arises from the delta cells of the pancreas, which produce somatostatin. The clinical manifestations of somatostatinoma are primarily related to the excess production of somatostatin, which inhibits the secretion of several hormones, including insulin and glucagon, leading to various gastrointestinal and metabolic effects.

The correct choice highlights the classic triad associated with somatostatinoma: mild diabetes, diarrhea, and gallstones. The inhibition of insulin secretion can lead to mild diabetes, characterized by hyperglycemia and impaired glucose tolerance. Diarrhea is often a result of the tumor's effects on gastrointestinal motility and secretion, leading to malabsorption. Additionally, somatostatin interferes with gallbladder contraction and can lead to the formation of gallstones due to altered bile flow and composition.

The other options do not align with the hallmark signs of somatostatinoma. For instance, vomiting, dehydration, and fever may suggest a different acute gastrointestinal process rather than the chronic conditions seen in somatostatinoma. Severe headache, jaundice, and pruritus may indicate an obstructive or hepatic issue, which does not reflect the typical presentation of this