What is the recommended dose of protamine for reversal of 5000 units of heparin intravenously?

The recommended dose of protamine for reversing heparin is typically calculated based on the amount of heparin administered. The general guideline is that protamine should be given in a dose of approximately 1 mg for every 100 units of heparin administered, with a maximum dose of protamine generally suggested to be in the range of 50 to 100 mg depending on the clinical scenario.

For a dose of 5000 units of intravenous heparin, the calculation would be as follows:

For 5000 units of heparin, the dose of protamine required would be 50 mg. This is based on the principle that for every 100 units of heparin, you give 1 mg of protamine, thus:

5000 units ÷ 100 units/mg = 50 mg of protamine.

This aligns with commonly used recommendations and protocols in clinical practice for heparin reversal. Therefore, choosing 50 mg protamine effectively neutralizes the anticoagulant effects of the administered heparin, making it the appropriate and recommended choice.