What is another primary risk associated with HNPCC specifically in women?

Women with Hereditary Non-Polyposis Colorectal Cancer (HNPCC), also known as Lynch syndrome, face a significantly increased risk for several types of cancers, particularly endometrial cancer. The connection between HNPCC and endometrial cancer is due to mutations in the DNA mismatch repair genes commonly associated with this syndrome.

Specifically, women with HNPCC have a lifetime risk of developing endometrial cancer that can be as high as 40-60%. This cancer often presents at a younger age compared to the general population, which emphasizes the importance of surveillance and preventive measures in these patients.

While other cancers such as breast and ovarian cancers are also considerations in women with HNPCC, the elevated risk for endometrial cancer is especially notable and serves as a key clinical feature for risk assessment and management in this population. Consequently, understanding this risk can aid in the implementation of appropriate screening protocols and early intervention strategies for women diagnosed with HNPCC.