What clinical features are associated with glucagonoma?

Glucagonoma is a rare type of pancreatic neuroendocrine tumor that results in an excess production of glucagon, a hormone that plays a major role in glucose metabolism. The condition is often associated with a specific skin rash known as necrolytic migratory erythema, which is a hallmark feature of glucagonoma. This rash typically appears as red, blistering lesions that can become crusted and progressively worsen, commonly affecting areas such as the groin, perineum, and legs.

In addition to the characteristic skin rash, patients may experience glossitis, which is inflammation of the tongue, presenting as a smooth, sore tongue that can make it painful to eat or speak. Mild diabetes can also be observed due to the effects of excess glucagon on insulin, leading to hyperglycemia.

The combination of these clinical features—mild diabetes, the distinctive skin rash, and glossitis—supports the association with glucagonoma, making this option the correct choice.

Other options present features that may describe different conditions, but they do not align with the signature symptoms associated with glucagonoma. For example, fatigue and excessive thirst might be more characteristic of conditions featuring severe hyperglycemia, but they do not