Peutz-Jeghers syndrome is associated with which of the following cancers?

Peutz-Jeghers syndrome is a genetic condition characterized by the formation of benign hamartomatous polyps in the gastrointestinal tract and mucocutaneous pigmentation. It is caused by mutations in the STK11 gene and has significant implications for cancer risk. Individuals with Peutz-Jeghers syndrome have an increased risk for several types of cancer, particularly colorectal cancer and pancreatic cancer.

When evaluating the options, the combination of colorectal cancer and sex cord tumors is particularly relevant. Colorectal cancer is a well-established risk associated with Peutz-Jeghers syndrome; patients have an increased lifetime risk of developing this type of cancer due to the presence of polyps. Moreover, sex cord tumors, particularly sex cord-stromal tumors of the ovaries, can also occur in individuals with Peutz-Jeghers syndrome, although they are less common.

Therefore, the option that encompasses both of these cancer types is the most accurate representation of the cancer risks associated with Peutz-Jeghers syndrome. This understanding highlights the importance of regular surveillance and screening for cancers in affected individuals to facilitate early detection and management.