In cases of VIPoma, what electrolytes are typically affected?

In cases of VIPoma, which is a tumor that secretes vasoactive intestinal peptide (VIP), the most commonly affected electrolytes include hypochloremia and hypokalemia. VIPoma leads to copious watery diarrhea due to increased intestinal secretions, which can result in significant fluid and electrolyte loss. The high volume of diarrhea primarily leads to the depletion of chloride and potassium in the body.

Hypochloremia occurs because the loss of gastrointestinal fluids, which are rich in chloride, exceeds the body’s ability to replace these electrolytes. Likewise, hypokalemia is a direct result of the body losing potassium with the excess gastrointestinal secretions. This pattern of electrolyte derangement is characteristic of the condition and helps in diagnostic considerations.

Understanding the interplay of these electrolyte changes in the context of VIPoma is essential for managing the patient's electrolyte balance and fluid therapy. Additionally, recognizing these specific electrolyte imbalances can guide further diagnostic evaluations and therapeutic interventions.